Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
skin and connective tissue diseases | D017437 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
AMELUZ | Biofrontera | N-208081 RX | 2016-05-10 | 1 products, RLD, RS |
GLEOLAN | NX Development | N-208630 RX | 2017-06-06 | 1 products, RLD, RS |
LEVULAN | Sun Pharmaceutical Industries | N-020965 RX | 1999-12-03 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
ameluz | New Drug Application | 2025-04-15 |
gleolan | New Drug Application | 2025-02-12 |
levulan kerastick | New Drug Application | 2024-09-12 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
actinic keratosis | — | D055623 | L57.0 |
Expiration | Code | ||
---|---|---|---|
AMINOLEVULINIC ACID HYDROCHLORIDE, GLEOLAN, NXDC | |||
2024-06-06 | ODE-146 |
Code | Description |
---|---|
J7308 | Aminolevulinic acid hcl for topical administration, 20%, single unit dosage form (354 mg) |
J7345 | Aminolevulinic acid hcl for topical administration, 10% gel, 10 mg |
Level 3: J7308-J7309 | Aminolevulinic Acid HCL |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Actinic keratosis | D055623 | — | L57.0 | 6 | 19 | 20 | 13 | 26 | 81 |
Glioma | D005910 | EFO_0000520 | — | 12 | 11 | 4 | 1 | 12 | 36 |
Keratosis | D007642 | — | — | 4 | 5 | 1 | 3 | 15 | 27 |
Basal cell carcinoma | D002280 | — | — | 4 | 7 | 7 | 1 | 3 | 19 |
Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | 8 | 3 | 5 | 17 |
Skin neoplasms | D012878 | EFO_0004198 | C44 | 3 | 4 | — | 1 | 3 | 10 |
Carcinoma | D002277 | — | C80.0 | 3 | 5 | 1 | 1 | 1 | 9 |
Recurrence | D012008 | — | — | 4 | 2 | 2 | 1 | — | 7 |
Bowen's disease | D001913 | — | D00-D09 | 1 | — | 1 | 1 | 2 | 5 |
Skin diseases | D012871 | — | L00-L99 | — | — | 2 | 1 | 2 | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Glioblastoma | D005909 | EFO_0000515 | — | 12 | 14 | 1 | — | 8 | 31 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | 11 | 14 | 1 | — | 7 | 30 |
Basal cell neoplasms | D018295 | — | — | 4 | 7 | 5 | — | 2 | 15 |
Squamous cell carcinoma | D002294 | — | — | — | 3 | 1 | — | 1 | 5 |
Precancerous conditions | D011230 | — | — | 1 | 1 | 2 | — | 1 | 5 |
Leukoplakia | D007971 | — | — | 2 | 2 | 1 | — | — | 4 |
Warts | D014860 | — | B07 | — | — | 1 | — | 3 | 4 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 1 | — | 1 | 2 |
Squamous cell neoplasms | D018307 | — | — | — | — | 1 | — | 1 | 2 |
Skin aging | D015595 | EFO_0005422 | — | — | 1 | 1 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acne vulgaris | D000152 | EFO_0003894 | L70 | 3 | 5 | — | — | 5 | 12 |
Neoplasms | D009369 | — | C80 | 2 | 3 | — | — | 3 | 8 |
Carcinoma in situ | D002278 | — | D09.9 | 1 | 5 | — | — | — | 6 |
Astrocytoma | D001254 | EFO_0000271 | — | 3 | 1 | — | — | 2 | 6 |
Photochemotherapy | D010778 | — | — | 1 | 2 | — | — | 3 | 5 |
Gliosarcoma | D018316 | — | — | 1 | 3 | — | — | — | 4 |
Uterine cervical dysplasia | D002578 | EFO_1000910 | N87 | 1 | 3 | — | — | — | 3 |
Colorectal neoplasms | D015179 | — | — | 2 | 3 | — | — | — | 3 |
Central nervous system neoplasms | D016543 | — | — | 1 | 2 | — | — | 1 | 3 |
Squamous intraepithelial lesions | D000081483 | — | — | — | 2 | — | — | 1 | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | 4 | 5 |
Communicable diseases | D003141 | — | — | 1 | — | — | — | 3 | 4 |
Pain | D010146 | EFO_0003843 | R52 | 2 | — | — | — | 1 | 3 |
Oligodendroglioma | D009837 | EFO_0000631 | — | 2 | — | — | — | 1 | 3 |
Wound infection | D014946 | — | — | 1 | — | — | — | 1 | 2 |
Surgical wound infection | D013530 | — | — | 1 | — | — | — | 1 | 2 |
Prostheses and implants | D019736 | — | — | 1 | — | — | — | 1 | 2 |
Prosthesis-related infections | D016459 | EFO_1001406 | — | 1 | — | — | — | 1 | 2 |
Healthy volunteers/patients | — | — | — | 1 | — | — | — | 1 | 2 |
Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | — | — | 3 | 3 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 2 | 2 |
Sars-cov-2 | D000086402 | — | — | — | — | — | — | 2 | 2 |
Erythropoietic porphyria | D017092 | — | — | — | — | — | — | 2 | 2 |
Porphyrias | D011164 | EFO_0000665 | — | — | — | — | — | 2 | 2 |
Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | — | — | — | 1 | 1 |
Psychological adaptation | D000223 | — | — | — | — | — | — | 1 | 1 |
Irritable mood | D007508 | — | — | — | — | — | — | 1 | 1 |
Environmental biomarkers | D000074062 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Aminolevulinic acid |
INN | — |
Description | 5-aminolevulinic acid is the simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. It has a role as a photosensitizing agent, an antineoplastic agent, a dermatologic drug, a prodrug, a plant metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a delta-amino acid and a 4-oxo monocarboxylic acid. It is functionally related to a 4-oxopentanoic acid. It is a conjugate base of a 5-ammoniolevulinic acid. It is a conjugate acid of a 5-aminolevulinate. It is a tautomer of a 5-ammoniolevulinate. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | NCC(=O)CCC(=O)O |